Clinical benefits of in-line IV filters
SUMMARY
Multiple clinical and in-vivo studies have highlighted the potential benefits of in-line IV filters for the most critically ill patients. In-vivo studies have shown that particles compromise microvascular circulation and in-line IV filters can prevent further loss of capillary density in vital organs. Clinical studies have shown that in-line IV filters may preserve organ function and reduce inflammation supporting improved outcomes for ICU patients.
What clinical benefits do IV in-line filters provide?
The impact of particles or the impact of IV in-line filters retaining particles on ICU patients has been in the spotlight of researchers and clinicians since 2008. Pall Medical IV filter has been and continues to be a driving force in this regard.
Several animal studies and human clinical trials have demonstrated the clinical benefits of using Pall IV in-line filters.
Animal models demonstrate that infusion of particles pose a major threat to critical tissue perfusion and that IV in-line filters prevent further reduction of postischemic functional capillary density. The results of the animal studies suggest that “in-line filters have potentially enormous relevance for patients with prior microvascular compromise of vital organs (i. e. post trauma, major surgery, sepsis).”1,2
Human clinical trials suggest that IV in-line filters have a positive impact on ICU patients by preserving organ functions and reducing inflammation rates.3-9
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References
1.Melchore JA. (2011). Sound practices for consistent human visual inspection. AAPS Pharm Sci Tech;12 (1): 215-221
2.Perez M. et al. (2017). Dynamic Image Analysis To Evaluate Subvisible Particles During Continuous Drug Infusion In a Neonatal Intensive Care Unit. Scientific Reports; 7 (9404): 1-8
3.Perez M. et al. (2018). Effectiveness of in-Line Filters to Completely Remove Particulate Contamination During a Pediatric Multidrug Infusion Protocol. Sci Rep; 8 (7714): 1-8
4.Keck C.M., Ngyen M., Pyo S. et al. (2016). How Many Nanoparticles Enter A Patient During Infusion Therapy? The Journal of Vascular Access; 17 (4): e8
5.Benlabed M. et al (2018). Analysis of particulate exposure during continuous drug infusion in critically ill adult patients: a preliminary proof-of concept in vitro study. Intensive Care Medicine Experimental; 6 (38): 1-9
6.Ernst C, Keller M., Eckstein J. (2012). Micro-Infusion Filters and Particulate Matter in Injections. Pharm. Ind; 74 (12): 2009-2020 (German Language)
7.Puntis J.W., Wilkins K.M., Ball P.A., Rushton D.I., Booth I.W. (1992). Hazards of parenteral treatment: do particles count?. Arch Dis Child;67 (12):1475-1477
8.Oie S, Kamiya A. (2005). Particulate and microbial contamination in in-use admixed parenteral nutrition solutions. Biol Pharm Bull; 28 (12): 2268-2270.
9.Ga Eul Joo, Kyeong‑Yae Sohng, Michael Yong Park. (2016). The effect of different methods of intravenous injection on glass particle contamination from ampules. SpringerPlus; 5 (15): 1-8
10.Perez M. et al. (2018). Effectiveness of in-Line Filters to Completely Remove Particulate Contamination During a Pediatric Multidrug Infusion Protocol. Sci Rep; 8 (7714): 1-8
11.Ernst C, Keller M., Eckstein J. (2012). Micro-Infusion Filters and Particulate Matter in Injections. Pharm. Ind; 74 (12): 2009-2020
Author bio
Dr. Volker Luibl, MBA
Dr. Luibl is a Sr. Marketing Manager Medical Content with knowledge in medical device and clinical science.
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